The Effect of Resveratrol on the Cardiovascular System from Molecular Mechanisms to Clinical Results.
Roland GalLaszlo DeresKalman TothRobert HalmosiTamas HabonPublished in: International journal of molecular sciences (2021)
Cardiovascular diseases are the leading causes of death worldwide. The cardioprotective effects of natural polyphenols such as resveratrol (3,5,4-trihydroxystilbene) have been extensively investigated throughout recent decades. Many studies of RES have focused on its favorable effects on pathological conditions related to cardiovascular diseases and their risk factors. The aim of this review was to summarize the wide beneficial effects of resveratrol on the cardiovascular system, including signal transduction pathways of cell longevity, energy metabolism of cardiomyocytes or cardiac remodeling, and its anti-inflammatory and antioxidant properties. In addition, this paper discusses the significant preclinical and human clinical trials of recent years with resveratrol on cardiovascular system. Finally, we present a short overview of antiviral and anti-inflammatory properties and possible future perspectives on RES against COVID-19 in cardiovascular diseases.
Keyphrases
- anti inflammatory
- cardiovascular disease
- risk factors
- clinical trial
- coronavirus disease
- sars cov
- endothelial cells
- cell therapy
- cardiovascular risk factors
- oxidative stress
- left ventricular
- single cell
- heart failure
- type diabetes
- stem cells
- randomized controlled trial
- cardiovascular events
- induced pluripotent stem cells
- mesenchymal stem cells
- atrial fibrillation
- respiratory syndrome coronavirus
- bone marrow
- phase ii
- single molecule