Associations Between Cancer Predisposition Mutations and Clonal Hematopoiesis in Patients With Solid Tumors.
Sebastià Franch-ExpósitoMiika MehineRyan N PtashkinKelly L BoltonChaitanya BandlamudiPreethi SrinivasanLinda ZhangMargaret A GoodellErika GedvilaiteKamal MenghrajaniPablo Sánchez VelaDiana L MandelkerElizabeth ComenLarry NortonRyma BenayedTeng GaoElli PapaemmanuilBarry S TaylorRoss LevineKenneth OffitZsofia K StadlerMichael F BergerAhmet ZehirPublished in: JCO precision oncology (2023)
Our results suggest a close relationship between inherited variants and CH mutations within the DDR genes in patients with solid tumors. Associations identified in this study might translate into enhanced clinical surveillance for CH and associated comorbidities in patients with cancer harboring these germline mutations.