The study of expression levels of DNA methylation regulators in patients affected with congenital heart defects (CHDs).

Radha O Joshi Prachi Kukshal Subramanian Chellappan Soma Guhathakurta

Published in: Birth defects research (2022)

Lower expression of de novo methyltransferases, namely, DNMT3B and DNMT3A in CHD cases, may be an important contributor to the mechanism of CHD pathogenesis. Further studies with age-matched controls and analysis of global DNA methylation profile are required to investigate the proposed causal association.

Keyphrases

dna methylation
poor prognosis
genome wide
gene expression
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
binding protein
transcription factor
long non coding rna
copy number