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Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxaemia: a pre-planned, secondary Bayesian analysis of the COVID STEROID 2 trial.

Anders GranholmMarie Warrer MunchSheila Nainan MyatraBharath Kumar Tirupakuzhi VijayaraghavanMaria CronhjortRebecka Rubenson WahlinStephan M JakobLuca CioccariMaj-Brit Nørregaard KjærGitte Kingo VesterlundTine Sylvest MeyhoffMarie HellebergMorten Hylander MøllerThomas BenfieldBalasubramanian VenkateshNaomi E HammondSharon MicallefAbhinav BassiOommen JohnVivekanand JhaKlaus Tjelle KristiansenCharlotte Suppli UlrikVibeke Lind JørgensenMargit SmittMorten H BestleAnne Sofie AndreasenLone Musaeus PoulsenBodil Steen RasmussenAnne Craveiro BrøchnerThomas StrømAnders MøllerMohd Saif KhanAjay PadmanabanJigeeshu Vasishtha DivatiaSanjith SaseedharanKapil BorawakeFarhad KapadiaSubhal DixitRajesh ChawlaUrvi ShuklaPravin AminMichelle S ChewChristian Aage WambergChristian GluudTheis LangeAnders Perner
Published in: Intensive care medicine (2021)
We found high probabilities of benefit and low probabilities of clinically important harm with dexamethasone 12 mg versus 6 mg daily in patients with COVID-19 and severe hypoxaemia on all outcomes up to 90 days.
Keyphrases
  • low dose
  • coronavirus disease
  • high dose
  • sars cov
  • early onset
  • clinical trial
  • physical activity
  • randomized controlled trial
  • metabolic syndrome
  • skeletal muscle