iPS cells from Chediak-Higashi syndrome patients recapitulate the giant granules in myeloid cells.
Shigeharu OhAkira NiwaAyako NagahashiIsao AsakaTatsutoshi NakahataMegumu K SaitoPublished in: Pediatrics international : official journal of the Japan Pediatric Society (2022)
We succeeded to reproduce a characteristic cellular phenotype, giant granules in myeloid cells, using CHS-iPSCs, demonstrating that iPSCs can be used to model the pathogenesis of CHS patients.