Expansion of FCGR3A+ macrophages, FCN1+ mo-DC, and plasmacytoid dendritic cells associated with severe skin disease in systemic sclerosis.
Dan XueTracy TabibChristina MorseYi YangRobyn T DomsicZsuzsanna H McMahanRobert A LafyatisPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
Transcriptional signatures in these and other myeloid populations indicate innate immune activation, possibly through TLRs, and highly upregulated chemokines. However, the appearance and activation of myeloid cells is variable between patients, indicating differing underlying pathogenesis and/or temporal disease activity.
Keyphrases
- dendritic cells
- systemic sclerosis
- disease activity
- immune response
- regulatory t cells
- innate immune
- rheumatoid arthritis
- interstitial lung disease
- systemic lupus erythematosus
- end stage renal disease
- rheumatoid arthritis patients
- induced apoptosis
- ejection fraction
- ankylosing spondylitis
- newly diagnosed
- prognostic factors
- gene expression
- chronic kidney disease
- transcription factor
- juvenile idiopathic arthritis
- cell cycle arrest
- patient reported outcomes
- bone marrow
- cell death
- oxidative stress
- dna methylation
- soft tissue
- cell proliferation
- signaling pathway
- drug induced
- pi k akt