EZH2-mediated inhibition of KLF14 expression promotes HSCs activation and liver fibrosis by downregulating PPARγ.

Zhipeng DuMei LiuZhihui WangZhuoying LinYangyang FengDean TianLimin Xia

Published in: Cell proliferation (2021)

KLF14 exerts a critical anti-fibrotic role in liver fibrosis, and targeting the EZH2/KLF14/PPARγ axis might be a novel therapeutic strategy for liver fibrosis.

Keyphrases

liver fibrosis
transcription factor
long non coding rna
poor prognosis
insulin resistance
long noncoding rna
systemic sclerosis
idiopathic pulmonary fibrosis
cancer therapy
binding protein
type diabetes
metabolic syndrome