Brain tight junction protein expression in sepsis in an autopsy series.

Kristo EriksonHannu TuominenMerja VakkalaJanne Henrik LiisananttiTuomo KarttunenHannu SyrjäläTero Ilmari Ala-Kokko

Published in: Critical care (London, England) (2020)

In fatal sepsis, damaged BBB defined as a loss of cerebral endothelial expression of occludin is related with severe organ dysfunction and systemic inflammation.

Keyphrases

blood brain barrier
septic shock
acute kidney injury
intensive care unit
cerebral ischemia
poor prognosis
endothelial cells
subarachnoid hemorrhage
oxidative stress
early onset
white matter
resting state
binding protein
long non coding rna
functional connectivity