Influence of SULT1A1*2 Polymorphism on Plasma Efavirenz Concentration in Thai HIV-1 Patients.
Monpat ChamnanphonRattanaporn SukprasongAndrea GaedigkWeerawat ManosuthiPajaree ChariyavilaskulSupeecha WittayalertpanyaNapatrupron KoomdeeThawinee JantararoungtongApichaya PuangpetchChonlaphat SukasemPublished in: Pharmacogenomics and personalized medicine (2021)
Genetic variation in a combination of SULT1A1*2 and SULT1A1 copy number may contribute to variability in EFV metabolism and thereby may impact drug response. The influence of a combination between the SULT1A1 and CYP2B6 genotype on EFV pharmacokinetics should be further investigated in a larger study population.
Keyphrases
- copy number
- mitochondrial dna
- end stage renal disease
- antiretroviral therapy
- hiv infected
- ejection fraction
- chronic kidney disease
- newly diagnosed
- genome wide
- human immunodeficiency virus
- prognostic factors
- hiv positive
- peritoneal dialysis
- dna methylation
- hiv testing
- gene expression
- adverse drug
- hiv infected patients
- patient reported outcomes
- men who have sex with men
- patient reported
- atomic force microscopy
- high speed