Sex-specific association of visceral and subcutaneous adipose tissue volumes with systemic inflammation and innate immune cells in people living with obesity.
Inge Christina Lamberta van den MunckhofHarsh BahrarKiki SchraaTessa BrandRob Ter HorstMarinette van der GraafHelena M DekkerRinke StienstraJacqueline de GraafLeo A B JoostenMihai M NeteaNiels P RiksenJoseph Henricus Wilhelmus RuttenPublished in: International journal of obesity (2005) (2023)
In women living with obesity, abdominal SAT volume, especially sSAT, is associated with circulating leukocytes and inflammatory proteins. In men, these parameters mainly show associations with VAT volume. This could be because only in women, sSAT volume is associated with sSAT expression of inflammatory proteins. These findings underscore that future research on adipose tissue in relation to cardiometabolic and cardiovascular disease should take sex differences into account.
Keyphrases
- insulin resistance
- adipose tissue
- polycystic ovary syndrome
- cardiovascular disease
- metabolic syndrome
- innate immune
- type diabetes
- high fat diet
- high fat diet induced
- weight loss
- oxidative stress
- induced apoptosis
- skeletal muscle
- poor prognosis
- pregnancy outcomes
- weight gain
- breast cancer risk
- body mass index
- pregnant women
- cell proliferation
- current status
- peripheral blood
- binding protein