CDKN1B Deletions are Associated with Metastasis in African American Men with Clinically Localized, Surgically Treated Prostate Cancer.

Farzana A FaisalSanjana MuraliHarsimar KaurThiago VidottoLiana B GuedesDaniela Correia SallesVishal KothariJeffrey J TosoianSumin HanDaniel H HovelsonKevin HuDaniel E SprattAlexander S BarasScott A TomlinsEdward M SchaefferTamara L Lotan

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Overall, PGA, somatic TP53 mutations, and a novel finding of deep deletions in CDKN1B were associated with poor prognosis in AA men. These findings require confirmation in additional AA cohorts.

Keyphrases

poor prognosis
african american
prostate cancer
long non coding rna
middle aged
radical prostatectomy
copy number
gene expression
newly diagnosed