Gene expression analysis to detect disseminated tumor cells in the bone marrow of triple-negative breast cancer patients predicts metastatic relapse.
Chidananda M SiddappaSreeraj G PillaiJackie SniderPatsy AlldredgeKathyrn TrinkausMark A WatsonRebecca AftPublished in: Breast cancer research and treatment (2019)
We identified a set of gene transcripts whose detection in the BM of TNBC patients, prior to any treatment intervention, predicts time to first distant relapse, thus identifying a TNBC patient population which requires additional treatment intervention. Because these genes are presumably expressed in populations of DTCs and many encode proteins that are known therapeutic targets (e.g., ERBB2), these results also suggest a potential approach for targeted DTC therapy to mitigate distant metastases in TNBC.
Keyphrases
- end stage renal disease
- gene expression
- bone marrow
- ejection fraction
- newly diagnosed
- chronic kidney disease
- randomized controlled trial
- small cell lung cancer
- peritoneal dialysis
- squamous cell carcinoma
- lymph node
- genome wide
- mesenchymal stem cells
- drug delivery
- climate change
- free survival
- tyrosine kinase
- case report
- smoking cessation
- cancer therapy
- cell therapy