Photoinduced Selective B-H Activation of nido -Carboranes.

The development of new synthetic methods for B-H bond activation has been an important research area in boron cluster chemistry, which may provide opportunities to broaden the application scope of boron clusters. Herein, we present a new reaction strategy for the direct site-selective B-H functionalization of nido -carboranes initiated by photoinduced cage activation via a noncovalent cage···π interaction. As a result, the nido -carborane cage radical is generated through a single electron transfer from the 3D nido -carborane cage to a 2D photocatalyst upon irradiation with green light. The resulting transient nido -carborane cage radical could be directly probed by an advanced time-resolved EPR technique. In air, the subsequent transformations of the active nido -carborane cage radical have led to efficient and selective B-N, B-S, and B-Se couplings in the presence of N-heterocycles, imines, thioethers, thioamides, and selenium ethers. This protocol also facilitates both the late-stage modification of drugs and the synthesis of nido -carborane-based drug candidates for boron neutron capture therapy (BNCT).