Optimization of the classical oral cancerization protocol in hamster to study oral cancer therapy.
Iara S Santa CruzMarcela A GarabalinoVerónica A TrivillinMaría E ItoizEmiliano C C PozziSilvia ThorpPaula CurottoJuan S GuidobonoElisa M HeberDavid W NiggAmanda Elena SchwintAndrea Monti HughesPublished in: Oral diseases (2020)
The twice-interrupted protocol reduced severe mucositis during cancerization without affecting tumor development. This favored the animal's welfare and reduced the number of animals to be cancerized for our studies, without affecting BNCT response.