Childhood Adiposity and Risk of Major Clinical Heart Diseases in Adulthood: A Mendelian Randomization Study.
Yan XiongYijia TangJie ZhouYang TianFuli ChenGang LiHui HuangHao HuangLong ZhouPublished in: Journal of the American Heart Association (2024)
Our findings support the causal relationships between childhood adiposity and risk of adult coronary heart disease, myocardial infarction, heart failure, and atrial fibrillation. Blood lipids, hypertension, and type 2 diabetes are factors that mediate the aforementioned associations.
Keyphrases
- heart failure
- atrial fibrillation
- type diabetes
- insulin resistance
- early life
- childhood cancer
- left ventricular
- blood pressure
- left atrial
- cardiovascular disease
- catheter ablation
- depressive symptoms
- weight gain
- left atrial appendage
- adipose tissue
- metabolic syndrome
- direct oral anticoagulants
- skeletal muscle
- young adults
- fatty acid
- weight loss
- mitral valve