Improving Harmonization and Standardization of Expanded Newborn Screening Results by Optimization of the Legacy Flow Injection Analysis Tandem Mass Spectrometry Methods and Application of a Standardized Calibration Approach.
Rachel S CarlingEmily WhyteCatharine JohnRachelle GarstonePhilippa GoddardToby GreenfieldSarah L HoggClare Le MasurierSimon CowenStuart J MoatChristopher HopleyPublished in: Clinical chemistry (2022)
For NBS programs provided by multiple laboratories using single analyte COVs, harmonization and standardization of results can be achieved by optimizing legacy FIA-MS/MS methods, adopting a common analytical protocol, and using standardized calibration material rather than internal calibration.
Keyphrases
- tandem mass spectrometry
- ultra high performance liquid chromatography
- liquid chromatography
- high performance liquid chromatography
- ms ms
- low cost
- gas chromatography
- simultaneous determination
- mass spectrometry
- high resolution mass spectrometry
- solid phase extraction
- randomized controlled trial
- public health
- liquid chromatography tandem mass spectrometry
- ultrasound guided