Pretreatment of aged mice with retinoic acid supports alveolar regeneration via upregulation of reciprocal PDGFA signalling.
Jason J GokeyJohn SnowballJenna GreenMarion WaltamathJillian J SpinneyKatharine E BlackLida P HaririYan XuAnne Karina PerlPublished in: Thorax (2021)
Our data support the concept that RA indirectly induces reciprocal PDGFA signalling, which activates regenerative fibroblasts that support alveolar epithelial cell differentiation and repair, providing a potential therapeutic strategy to influence the pathogenesis of IPF.
Keyphrases
- stem cells
- idiopathic pulmonary fibrosis
- rheumatoid arthritis
- mesenchymal stem cells
- poor prognosis
- electronic health record
- cell proliferation
- high fat diet induced
- signaling pathway
- disease activity
- extracellular matrix
- type diabetes
- metabolic syndrome
- adipose tissue
- machine learning
- wild type
- long non coding rna
- deep learning