Inflammation in acute coronary syndrome: Expression of TLR2 mRNA is increased in platelets of patients with ACS.

Lukas Andreas HegerMarcus HortmannMadlin AlbrechtChristian ColbergKarlheinz PeterThilo WitschDaniela StallmannAndreas ZirlikChristoph BodeDaniel DuerschmiedIngo Ahrens

Published in: PloS one (2019)

Our results suggest elevated TLR2 mRNA expression in platelets as a biomarker reflecting the underlying inflammation in ACS and possibly severity of coronary atherosclerosis. Platelet TLR2 may represent a link between inflammation and atherothrombosis in ACS.

Keyphrases

acute coronary syndrome
oxidative stress
toll like receptor
inflammatory response
percutaneous coronary intervention
antiplatelet therapy
immune response
coronary artery disease
coronary artery
cardiovascular disease
poor prognosis
nuclear factor
binding protein
aortic stenosis