Effects of human rhinovirus on epithelial barrier integrity and function in children with asthma.

K LooiA G BuckleyP J RigbyL W GarrattT IosifidisG R ZoskyA N LarcombeF J LanniganK-M LingK M MartinovichE Kicic-StarcevichN C ShawE N SutantoD A KnightAnthony KicicS M Stick

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2018)

This study demonstrates novel intrinsic differences in TJ gene and protein expression between AEC of children with and without asthma. Furthermore, it correlates directly the relationship between HRV infection and the resultant dissociation of epithelial TJ that causes a continued altered barrier function in children with asthma.

Keyphrases

chronic obstructive pulmonary disease
young adults
lung function
endothelial cells
allergic rhinitis
gene expression
cystic fibrosis
pluripotent stem cells
electron transfer