Antifibrosis treatment by inhibition of VEGF, FGF, and PDGF receptors improves bladder wall remodeling and detrusor overactivity in association with modulation of C-fiber afferent activity in mice with spinal cord injury.
Joonbeom KwonEun-Ju LeeHyun-Jung ChoJi-Ae JangMin-Su HanEunkyoung KwakHaesoo KimJihyun AnDonghwi ParkSeungwoo HanNobutaka ShimizuTakahisa SuzukiEi-Ichiro TakaokaNaoki YoshimuraPublished in: Neurourology and urodynamics (2021)
Nintedanib improves storage and voiding dysfunctions and bladder fibrosis in SCI mice. Also, nintedanib-induced improvement of DO is associated with reduced expression of C-fiber afferent markers, suggesting the modulation of bladder C-fiber afferent activity.
Keyphrases
- spinal cord injury
- idiopathic pulmonary fibrosis
- high fat diet induced
- poor prognosis
- interstitial lung disease
- high glucose
- endothelial cells
- diabetic rats
- type diabetes
- insulin resistance
- wild type
- systemic sclerosis
- metabolic syndrome
- drug induced
- binding protein
- long non coding rna
- vascular smooth muscle cells
- angiotensin ii