Adipose tissue protects against sepsis-induced muscle weakness in mice: from lipolysis to ketones.
Chloë GoossensRuben WeckxSarah DerdeThomas DufourSarah Vander PerreLies PauwelsSteven E ThiessenPaul P Van VeldhovenGreet Van den BergheLies LangouchePublished in: Critical care (London, England) (2019)
Obesity-induced muscle protection during sepsis is partly mediated by elevated mobilization and metabolism of endogenous fatty acids. Furthermore, increased availability of ketone bodies, either through ketogenesis or through parenteral infusion, appears to protect against sepsis-induced muscle weakness also in the lean.