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In chronic lymphocytic leukaemia, SLAMF1 deregulation is associated with genomic complexity and independently predicts a worse outcome.

Gian Matteo RigolinElena SaccentiAurora MelandriMaurizio CavallariAntonio UrsoFrancesco RotondoAnita BetullaLucia TognoloMaria Antonella BardiMarika RossiniElisa TammisoChristian BassiFrancesco CavazziniMassimo NegriniAntonio Cuneo
Published in: British journal of haematology (2020)
In a series of 349 patients with chronic lymphocytic leukaemia (CLL), we found lower levels of signalling lymphocytic activation molecule family member 1 (SLAMF1) expression in cases with highly complex karyotypes, as defined by the presence of five or more chromosomal abnormalities (CK5; P < 0·001) and with major chromosomal structural abnormalities (P < 0·001). SLAMF1 downregulation was significantly associated with advanced Binet Stage (P = 0·001), CD38 positivity (P < 0·001), high β2 -microglobulin levels (P < 0·001), immunoglobulin heavy chain variable region gene (IGHV) unmutated status (P < 0·001), 11q deletion (P < 0·001), tumour protein p53 (TP53) disruption (P = 0·011) and higher risk CLL International Prognostic Index categories (P < 0·001). Multivariate analysis showed that downregulated SLAMF1 levels had independent negative prognostic impact on time-to-first treatment (P < 0·001) and overall survival (P < 0·001).
Keyphrases
  • copy number
  • poor prognosis
  • cell proliferation
  • binding protein
  • chronic lymphocytic leukemia
  • data analysis
  • amino acid
  • protein protein
  • replacement therapy
  • genome wide analysis