Thioguanine is effective as maintenance therapy for inflammatory bowel disease: a prospective multicentre registry study.
Melek SimsekFemke SchepersSigal KaplanDirk van AsseldonkPetra van BoeckelPaul BoekemaGerard DijkstraHerma FidderIngrid GisbertzFrank HoentjenBindia JharapFrank KubbenMarleen de LeestMaarten MeijssenAna PetrakElse van de PoelMaurice RusselAdriaan A van BodegravenChris J J MulderNanne de BoerPublished in: Journal of Crohn's & colitis (2023)
Sustained corticosteroid-free clinical remission over 12 months was achieved in 45% of IBD patients on monotherapy with thioguanine. A drug continuation rate of 80%, together with favourable PGA and QoL scores, underlines the tolerability and effectiveness of thioguanine for IBD.