Weekly split-dose regimen for oral methotrexate reduced polyglutamation in red blood cells in patients with rheumatoid arthritis compared with single-dose regimen: Results from a multicentered randomized control trial.

Shouhei NagaokaKou KatayamaTsuyoshi KasamaMasao SatoShigeru OhnoYoshiharu AmasakiHiroshi KataokaAkira FurusakiYujiro KonMasahiro OkamotoMinoru SasanoAkira Sagawa

Published in: International journal of rheumatic diseases (2020)

Weekly split dosing reduced the polyglutamation of MTX. There was no significant difference in efficacy and safety between the 2 groups.

Keyphrases

red blood cell
double blind
open label
placebo controlled
phase iii
phase ii
clinical trial
randomized controlled trial
low dose
study protocol