Weekly split-dose regimen for oral methotrexate reduced polyglutamation in red blood cells in patients with rheumatoid arthritis compared with single-dose regimen: Results from a multicentered randomized control trial.
Shouhei NagaokaKou KatayamaTsuyoshi KasamaMasao SatoShigeru OhnoYoshiharu AmasakiHiroshi KataokaAkira FurusakiYujiro KonMasahiro OkamotoMinoru SasanoAkira SagawaPublished in: International journal of rheumatic diseases (2020)
Weekly split dosing reduced the polyglutamation of MTX. There was no significant difference in efficacy and safety between the 2 groups.