Neuroplasticity of ascending and descending pathways after somatosensory system injury: reviewing knowledge to identify neuropathic pain therapeutic targets.
Núria FiolS CastanyJ HomsB Álvarez-PérezM DeulofeuE VerdúPublished in: Spinal cord (2016)
Neuropathic pain triggered by traumatic lesions leads to sensitization and hyperexcitability of nociceptors and projection neurons of the dorsal horn, a strengthening in the descendent excitatory pathway and an inhibition of the descending inhibitory pathway of pain. These functional events are associated with molecular plastic changes such as overexpression of voltage-gated ion channels, algogen-sensitive receptors and synthesis of several neurotransmitters. Molecular studies on the plastic changes in the nociceptive somatosensory system enable the development of new pharmacological treatments against neuropathic pain, with higher specificity and effectiveness than classical drug treatments. Although research efforts have already focused on these aspects, additional research may be necessary to further explore the potential therapeutic targets in neuropathic pain involved in the neuroplasticity changes of neuropathological pathways from the injured somatosensory system.
Keyphrases
- neuropathic pain
- spinal cord injury
- spinal cord
- transcranial direct current stimulation
- randomized controlled trial
- healthcare
- systematic review
- cell proliferation
- magnetic resonance imaging
- emergency department
- computed tomography
- transcription factor
- chronic pain
- magnetic resonance
- pulmonary artery
- image quality
- pulmonary arterial hypertension
- structural basis