Longitudinal Gray Matter Trajectories in Pediatric Mild Traumatic Brain Injury.

These findings signal little diagnostic and prognostic utility of post-acute gray matter macrostructure in pediatric mTBI. However, mTBI altered the typical course of cortical gray matter thinning up to 6 months post-injury, even after symptoms typically abate in most children. Collapsing across symptom status obscured the neurobiological heterogeneity of discrete clinical outcomes after pediatric mTBI. Results illustrate the need to examine neurobiology in relation to clinical outcomes and within a neurodevelopmental framework.