DNA CpG methylation in sequential glioblastoma specimens.
Zoltán KrabothBence GalikMarton TompaBela KajtarPeter UrbanAttila GyeneseiAttila MisetaBernadette KalmanPublished in: Journal of cancer research and clinical oncology (2020)
DNA CpG methylation analyses in sequential clinical specimens revealed hypomethylation in certain pathways such as neuronal tissue development and angiogenesis likely involved in early tumor development and growth, while suggested altered regulation in catecholamine secretion and transport, Wnt expression and immune response contributing to glioblastoma recurrence. These pathways merit further investigations and may represent novel therapeutic targets.