A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes.

Jin-Gu Lee Yulong Fu Jun-Yi Zhu Pei Wen Joyce van de Leemput Patricio E Ray Zhe Han

Published in: Cell & bioscience (2023)

Using a Drosophila screen, we identified SNARE proteins (Syx7, Ykt6, and Syb) as antagonists of APOL1-induced cytotoxicity by directly binding APOL1. These data uncovered a new potential protective role for certain SNARE proteins in the pathogenesis of APOL1-CKD and provide novel therapeutic targets for APOL1-associated nephropathies.

Keyphrases

chronic kidney disease
oxidative stress
high throughput
high glucose
electronic health record
endothelial cells
deep learning
binding protein
dna binding