Epitope spreading driven by the joint action of CART cells and pharmacological STING stimulation counteracts tumor escape via antigen-loss variants.

Enrique CondeEnric VercherMarta Soria-CastellanoJesús Suarez-OlmosUxua MancheñoEdurne ElizaldeM Luis RodriguezJavier Glez-VazNoelia CasaresEstefanía Rodríguez-GarcíaMirja HommelGloria González-AseguinolazaIratxe Uranga-MurilloJulian PardoGorka AlkortaIgnacio Melero Bermejo Juan Jose Lasarte Sandra Hervás-Stubbs

Published in: Journal for immunotherapy of cancer (2022)

Our data show that 2'3'-cGAMP is a suitable adjuvant to combine with CART-cell therapy, allowing the induction of an endogenous T-cell response that prevents the outgrowth of Ag-loss tumor variants.

Keyphrases

cell therapy
copy number
induced apoptosis
early stage
cell cycle arrest
electronic health record
quantum dots
big data
mouse model
endoplasmic reticulum stress
cell proliferation
highly efficient
pi k akt
bone marrow