High efficacy of CD19 CAR T-cells in patients with transformed Waldenström macroglobulinemia.

Eric DurotDamien RoosweilAdrien ChauchetJustine DecroocqRoberta Di BlasiThomas GastinneHedi BensaberMorgane CheminantCaroline JacquetStéphanie GuidezFrançois-Xavier Gros Emmanuel Bachy Arthur CostePascale Cony-MakhoulSteven P Treon Alain Jacques DelmerRan ReshefSteven Le Gouill Jorge J Castillo Houot Roch

Published in: Blood (2024)

Histological transformation of Waldenström macroglobulinemia (HT-WM) carries a poor prognosis with standard treatments. Here, we report the first series of HT-WM treated with CAR T-cells showing a high efficacy and no unexpected toxicity.

Keyphrases

poor prognosis
long non coding rna
induced apoptosis
oxidative stress
cell cycle arrest
endoplasmic reticulum stress
signaling pathway
cell death
cell proliferation