Combined Transplantation of Human MSCs and ECFCs Improves Cardiac Function and Decrease Cardiomyocyte Apoptosis After Acute Myocardial Infarction.
Himi TripathiAlison DominguesRenee DonahueAudrey CrasCoralie L GuerinErhe GaoBryana LevitanMariusz Z RatajczakDavid M SmadjaAhmed Abdel-LatifWadea M TarhuniPublished in: Stem cell reviews and reports (2022)
The use of ECFCs, MSCs, and the combination of both cell types reduce cardiomyocyte apoptosis, scar size, and adverse cardiac remodeling, compared to vehicle, in a pre-clinical model of AMI. These results support the use of this combined cell therapy approach in future human studies during the acute phase of ischemic cardiac injury.
Keyphrases
- cell therapy
- acute myocardial infarction
- mesenchymal stem cells
- endothelial cells
- left ventricular
- oxidative stress
- stem cells
- endoplasmic reticulum stress
- cell cycle arrest
- cell death
- induced pluripotent stem cells
- pluripotent stem cells
- umbilical cord
- angiotensin ii
- high glucose
- single cell
- heart failure
- emergency department
- bone marrow
- ischemia reperfusion injury
- coronary artery disease
- current status
- adverse drug
- wound healing
- pi k akt