The Inter-Organ Crosstalk Reveals an Inevitable Link between MAFLD and Extrahepatic Diseases.
Tsubasa TsutsumiDan NakanoRyuki HashidaTomoya SanoMachiko KawaguchiKeisuke AmanoTakumi KawaguchiPublished in: Nutrients (2023)
Fatty liver is known to be associated with extra-hepatic diseases including atherosclerotic cardiovascular disease and extra-hepatic cancers, which affect the prognosis and quality of life of the patients. The inter-organ crosstalk is mediated by metabolic abnormalities such as insulin resistance and visceral adiposity. Recently, metabolic dysfunction-associated fatty liver disease (MAFLD) was proposed as a new definition for fatty liver. MAFLD is characterized by the inclusion criteria of metabolic abnormality. Therefore, MAFLD is expected to identify patients at high risk of extra-hepatic complications. In this review, we focus on the relationships between MAFLD and multi-organ diseases. We also describe the pathogenic mechanisms of the inter-organ crosstalk.
Keyphrases
- insulin resistance
- cardiovascular disease
- end stage renal disease
- type diabetes
- metabolic syndrome
- ejection fraction
- newly diagnosed
- adipose tissue
- fatty acid
- risk factors
- skeletal muscle
- prognostic factors
- peritoneal dialysis
- high fat diet induced
- physical activity
- coronary artery disease
- body mass index
- patient reported