The expression of stromal biomarkers in small papillary thyroid carcinomas.
Haytham BayadsiGeorge BarghoutMoa GustafssonMalin SundJoakim HenningsPublished in: World journal of surgical oncology (2022)
Col1, Col4, a-SMA, and MMP-9 expression in PTCs differs significantly from that of normal thyroid tissue. The higher expression of Col1 and Col4 in normal thyroid tissue and in the non-metastasized tumors indicates that Col1 and 4 might have a potential protective role in tumor progression. The higher expression of a-SMA and MMP9 in PTCs indicates that these proteins might have a role in promoting PTC progression and aggressiveness.