Transcriptional and immunological analysis of the putative outer membrane protein and vaccine candidate TprL of Treponema pallidum.
Austin M HaynesMark FernandezEmily RomeisOriol MitjàKelika E KondaSilver K VargasMaria EguiluzCarlos F CaceresJeffrey D KlausnerLorenzo GiacaniPublished in: PLoS neglected tropical diseases (2021)
The ability of T. p. pallidum to stochastically vary tprL expression should be considered in any vaccine development effort that includes this antigen. The role of phase variation in contributing to T. p. pallidum antigenic diversity should be further studied.