Diffuse pleural mesotheliomas with genomic near-haploidization: a newly recognized subset with distinct clinical, histologic, and molecular features.

Soo-Ryum Yang Gowtham Jayakumaran Jamal K Benhamida Christopher Antonio Febres-Aldana Rachel Fanaroff Jason C Chang Erika Gedvilaite Liliana B Villafania Jennifer L Sauter Michael D Offin Marjorie G Zauderer Marc Ladanyi

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

GNH defines an aggressive subtype of mainly biphasic DPMs in younger patients with recurrent alterations in SETDB1 and TP53. The enrichment in biphasic histology and TILs, together with our preliminary ICB response data and anecdotal clinical trial data, suggests that further evaluation of immunotherapy may be warranted in this subset.

Keyphrases

clinical trial
electronic health record
big data
low grade
randomized controlled trial
study protocol
machine learning
copy number
gene expression
open label
high grade