Oral coenzyme Q10 supplementation in patients with migraine: Effects on clinical features and inflammatory markers.
Monireh DahriAli Tarighat-EsfanjaniMohammad Asghari JafarabadiMazyar HashemilarPublished in: Nutritional neuroscience (2018)
Backgrounds and aims: Migraine and inflammation are correlated. Coenzyme Q10 (CoQ10) as an anti-inflammatory agent has shown useful effects in other diseases. The present study aimed to assess the effect of CoQ10 supplementation on inflammation and clinical features of migraine. Methods: This randomized double-blind placebo-controlled clinical trial was conducted among 45 non-menopausal women aged 18-50 years, diagnosed for episodic migraine according to the International Headache Society. After one month run-in period, subjects received CoQ10 (400 mg/day CoQ10, n = 23) or placebo (wheat starch, n = 22) for three months. All the patients got prophylactic medication too. Serum CoQ10 concentration, Calcitonin gene-related peptide (CGRP), interleukin (IL)-6, IL-10 and tumor necrosis factor-α (TNF-α) were measured at the beginning and end of the study. Results: CoQ10 supplementation reduced CGRP and TNF-α significantly (p = 0.011 and p = 0.044, respectively), but there were no significant differences in serum IL-6 and IL-10 between the two groups. Significant increase in serum CoQ10 levels was evident with CoQ10 therapy (P < 0.001). A significant improvement was found in frequency (p = 0.018), severity (p = 0.001) and duration (p = 0.012) of migraine attacks in CoQ10 group compared to placebo. Conclusion: CoQ10 supplementation may decrease CGRP and TNF-α with no favorable effects on IL-6 and IL-10 in patients with migraine.
Keyphrases
- double blind
- placebo controlled
- clinical trial
- phase iii
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- phase ii
- oxidative stress
- open label
- end stage renal disease
- study protocol
- type diabetes
- emergency department
- chronic kidney disease
- gene expression
- phase ii study
- stem cells
- ejection fraction
- skeletal muscle
- newly diagnosed
- transcription factor
- metabolic syndrome
- randomized controlled trial
- mesenchymal stem cells
- patient reported outcomes
- radiation therapy
- dna methylation
- bone marrow
- genome wide
- adipose tissue
- genome wide identification