Hormonal and metabolic effects of carbohydrate restriction in children with Prader-Willi syndrome.
Krystal A IrizarryDiana R MagerLucila TriadorMichael J MuehlbauerAndrea M HaqqMichael FreemarkPublished in: Clinical endocrinology (2019)
Increases in GLP-1 with low carbohydrate feeding and reductions in the ratio of ghrelin to GLP-1 might limit food intake and improve glycaemic control in PWS. Other potential benefits of carbohydrate restriction may include fat mobilization and oxidation and reductions in the TG/HDL ratio, a marker of insulin resistance. However, increases in CRP, AST and ALT necessitate longer-term studies of low carbohydrate efficacy and safety.