Prevalence of Selected Single-Nucleotide Variants in Patients with Neuroendocrine Tumors-Potential Clinical Relevance.

Anna KurzyńskaDorota PachAnna Elżbieta SkalniakAgnieszka StefańskaMarta Opalińska Elwira Maria Przybylik-MazurekAlicja Hubalewska-Dydejczyk

Published in: Journal of clinical medicine (2022)

Our study indicates that GG homozygotes of variant rs1800872 are more often observed in NET patients, while TT homozygotes of variant rs3731198 are less frequent in this group. The rs3731198 variant may be related to an increased risk of lymph node metastasis. Further, larger multicenter studies are warranted to evaluate the potential genetic factors of sporadic NETs.

Keyphrases

lymph node metastasis
neuroendocrine tumors
end stage renal disease
squamous cell carcinoma
ejection fraction
newly diagnosed
copy number
chronic kidney disease
risk factors
prognostic factors
papillary thyroid
clinical trial
late onset
genome wide
cross sectional
early onset
drug induced