Inflammatory markers in cerebrospinal fluid: independent prognostic biomarkers in amyotrophic lateral sclerosis?

Benjamin GilleMaxim De SchaepdryverLieselot DedeeneJanne GoossensKristl G ClaeysLudo Van Den BoschJos TournoyPhilip Van Damme Koen Poesen

Published in: Journal of neurology, neurosurgery, and psychiatry (2019)

Our findings show that inflammation in patients with ALS reflects the disease progression as an independent predictor of survival. Our data encourage the use of inflammatory markers in patient stratification and as surrogate markers of therapy response in clinical trials.

Keyphrases

cerebrospinal fluid
clinical trial
oxidative stress
case report
electronic health record
big data
amyotrophic lateral sclerosis
stem cells
machine learning