ACE phenotyping in human heart.
Victoria E TikhomirovaOlga A KostOlga V KryukovaElena Z GolukhovaNaida I BulaevaAigerim Z ZholbaevaLeo A BokeriaJoe G N GarciaSergei M DanilovPublished in: PloS one (2017)
Significant differences in the local conformations and kinetic properties of heart and lung ACEs demonstrate tissue specificity of ACE and provide a structural base for the development of mAbs able to distinguish heart and lung ACEs as a potential blood test for predicting atrial fibrillation risk.
Keyphrases
- atrial fibrillation
- heart failure
- endothelial cells
- angiotensin ii
- angiotensin converting enzyme
- oral anticoagulants
- catheter ablation
- left atrial
- left atrial appendage
- direct oral anticoagulants
- high throughput
- percutaneous coronary intervention
- left ventricular
- pluripotent stem cells
- single cell
- human health
- venous thromboembolism