A novel lncRNA MCM3AP-AS1 promotes the growth of hepatocellular carcinoma by targeting miR-194-5p/FOXA1 axis.

Yufeng WangLiu YangTianxiang ChenXin LiuYang GuoQiaojuan ZhuXiangmin TongWei YangQiuran XuDongsheng HuangKangsheng Tu

Published in: Molecular cancer (2019)

Our results recognized MCM3AP-AS1 as a novel oncogenic lncRNA, which indicated poor clinical outcomes in patients with HCC. MCM3AP-AS1 exerted an oncogenic role in HCC via targeting miR-194-5p and subsequently promoted FOXA1 expression. Our findings suggested that MCM3AP-AS1 could be a potential prognostic biomarker and therapeutic target for HCC.

Keyphrases

transcription factor
long non coding rna
poor prognosis
long noncoding rna
cancer therapy
drug delivery
risk assessment