Emulsified silicone oil is taken up by and induces pro-inflammatory response in primary retinal microglia.

Alexa KlettnerAntonia HarmsVicki WaetzigJan TodeKonstantine PurtskhvanidzeJohann Roider

Published in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2020)

Emulsified silicone oil changes the activity level of microglia and induces the secretion of IL-6 and IL-8. Neurotoxicity is not induced. Further experiments are required to investigate the long-term effect of silicone oil on microglia and their consequent effect on neuronal cells.

Keyphrases

inflammatory response
lipopolysaccharide induced
lps induced
toll like receptor
fatty acid
neuropathic pain
induced apoptosis
cell cycle arrest
high glucose
optical coherence tomography
diabetic retinopathy
diabetic rats
endothelial cells
immune response
spinal cord
spinal cord injury
cell death