Retrospective analysis of the association of the expression and single nucleotide polymorphisms (SNPs) of the TLR4, PTX3 and Dectin-1 (CLEC/A) genes with development of invasive aspergillosis among haematopoietic stem cell transplant recipients with oncohaematological disorders.
Ayşe KalkancıEsra TugIsil FidanOzlem Guzel TunccanZubeyde Nur OzkurtZeynep Arzu YeginElif Ayça SahinZeynep KuralayPublished in: Mycoses (2020)
TLR4, PTX3 and Dectin-1 genes were downregulated in aspergillosis cohort under similar haematological conditions. TLR4 expression was 0.0626 ± 0.032 in controls when compared to IA patients as 0.0077 ± 0.014, and the difference was significant (P = .026). There was a difference in also the PTX3 gene among IA (0.0043 ± 0.004) and control (0.5265 ± 0.0043) groups (P = .035). The Dectin-1 (CLEC/A) expression was downregulated in IA group (0.1887 ± 0.072 & 0.0655 ± 0.010) but not statistically significant (P > .05). Conditional logistic regression analyses indicated that the GT genotype of rs16910526 polymorphism in Dectin-1 gene was associated with lower risk of IA (odds ratio = 3.635, 95% confidence interval = 0.690-3.138, P = .04).
Keyphrases
- genome wide
- poor prognosis
- toll like receptor
- stem cells
- inflammatory response
- genome wide identification
- immune response
- end stage renal disease
- newly diagnosed
- ejection fraction
- copy number
- binding protein
- chronic kidney disease
- dna methylation
- long non coding rna
- prognostic factors
- gene expression
- transcription factor
- bone marrow
- bioinformatics analysis
- patient reported