A Novel Prognostic Biomarker LPAR6 in Hepatocellular Carcinoma via Associating with Immune Infiltrates.

Jian HeMei MengHui Wang

Published in: Journal of clinical and translational hepatology (2021)

Our results imply that LPAR6 is associated with prognosis potential and immune infiltration levels in liver cancer. Moreover, LPAR6 expression possibly contributes to the activation of CD8+ T, naive T, effector T cells and natural killer cells and inactivates T regulatory cells, decreases T cell exhaustion and regulate T helper cells in liver cancer. These discoveries imply that LPAR6 could be a novel biomarker of prognosis for indicating prognosis potential and immune-infiltrating level in hepatocellular carcinoma.

Keyphrases

induced apoptosis
cell cycle arrest
natural killer cells
regulatory t cells
dendritic cells
poor prognosis
endoplasmic reticulum stress
hiv infected
human health
long non coding rna
pi k akt