Disulfiram Enhances the Activity of Polymyxin B Against Klebsiella pneumoniae by Inhibiting Lipid A Modification.

Wei Huang Jin-Yong Zhang Shiyi LiuChunxia HuMin ZhangShumin ChengHuijuan YuManling ZhengJinsong WuYuemei LuQuanming ZouRuiqin Cui

Published in: Infection and drug resistance (2022)

We identified a new drug combination that can be used to reduce the necessary dosage of PB and overcome PB resistance, and this drug combination has good prospects for clinical application.

Keyphrases

klebsiella pneumoniae
multidrug resistant
heavy metals
escherichia coli
signaling pathway
gram negative
aqueous solution
drug induced
current status
fatty acid
risk assessment
emergency department
electronic health record