CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst.
Sebastián ZagmuttPaula MeraIsmael González-GarcíaKevin IbeasMaría Del Mar RomeroArnaud ObriBeatriz MartinAnna Esteve-CodinaM Carmen Soler-VázquezMarianela Bastias-PérezLaia CañesElisabeth AugéCarme PelegriJordi VilaplanaXavier ArizaJordi GarcíaJosé Martinez-GonzálezNúria CasalsMiguel LópezRichard PalmiterElisenda SanzAlbert QuintanaLaura HerreroDolors SerraPublished in: Biology of sex differences (2023)
Our results highlight that fatty acid metabolism and CPT1A in AgRP neurons show marked sex differences and play a relevant role in the neuronal processes necessary for the maintenance of whole-body fluid and energy balance.
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