Assessment of the Level of Matrix Metalloproteinases, VEGF and MicroRNA-34a in Patients With Non-obstructive and Obstructive Lesions of the Coronary Arteries.
A O IusupovaO A SlepovaN N PakhtusovL V PopovaA A AgeevA S LishutaE V PrivalovaN V KhabarovaG М DadashovаYu N BelenkovPublished in: Kardiologiia (2024)
IHD patients with INOCAD had the greatest increase in MMP-1, whereas patients with obstructive CA disease had the highest level of MMP-9. According to our data, concentrations of MMP-9 and VEGF can be used to predict the degree of CA obstruction. The expression of miRNA-34a was significantly higher in IHD patients with INOCAD and CA obstruction than in the control group, which suggested a miRNA-34a contribution to the development and progression of coronary atherosclerosis. In the future, it may be possible to use this miRNA as a diagnostic marker for IHD.
Keyphrases
- coronary artery disease
- coronary artery
- vascular endothelial growth factor
- cell migration
- endothelial cells
- poor prognosis
- protein kinase
- cardiovascular disease
- aortic stenosis
- electronic health record
- type diabetes
- big data
- current status
- transcatheter aortic valve replacement
- atrial fibrillation
- aortic valve
- blood flow