The heart rate variability-derived Newborn Infant Parasympathetic Evaluation (NIPE™) Index in pediatric surgical patients from 0 to 2 years under sevoflurane anesthesia-A prospective observational pilot study.
Frank WeberHilde G RoeleveldNoortje J E GeertsAnnejet T WarmenhovenRosalie SchröderThomas G de LeeuwPublished in: Paediatric anaesthesia (2019)
In infants anesthetized with sevoflurane, NIPE values <50 might be indicative of insufficient antinociception. The results of this observational pilot study might suggest that the NIPE could be a better measure of the nociception/antinociception balance than heart rate.