The Inhibition of P-Selectin Reduced Severe Acute Lung Injury in Immunocompromised Mice.
Yang LiuDu XiangFang GaoHanlin YaoQi-Fa YeYanfeng WangPublished in: Oxidative medicine and cellular longevity (2020)
In an immunocompetent host, excess infiltration of immune cells in the lung is a key factor in infection-induced severe acute lung injury. Kidney transplant patients are immunocompromised by the use of immunosuppressive drugs. Immune cell infiltration in the lung in a renal transplant recipient suffering from pulmonary infection is significantly less than that in an immunocompetent host; however, the extent of lung injury in renal transplant patients is more serious than that in immunocompetent hosts. Therefore, we explored the role of platelet activation in a Klebsiella pneumoniae-induced lung injury model with P-selectin gene knockout mice or wild-type mice. Our study suggested that the inhibition of platelets reduced severe acute lung injury and increased survival after acute lung infection in mice. In addition, P-selectin expression on the surface of platelets in mice increased after administration of immunosuppressive drugs, and the extent of lung injury induced by infection decreased in P-selectin gene knockout mice. In conclusion, p-selectin plays a key role in severe acute lung injury in immunocompromised mice by reducing platelet activation and inflammatory processes.
Keyphrases
- wild type
- lipopolysaccharide induced
- high fat diet induced
- lps induced
- drug induced
- end stage renal disease
- ejection fraction
- newly diagnosed
- klebsiella pneumoniae
- early onset
- inflammatory response
- poor prognosis
- insulin resistance
- multidrug resistant
- oxidative stress
- high glucose
- metabolic syndrome
- diabetic rats
- skeletal muscle
- gene expression
- copy number
- intensive care unit
- adipose tissue
- respiratory failure