The burden of mitochondrial disease with associated seizures: systematic literature reviews of health-related quality of life, utilities, costs and healthcare resource use data.
Enrico BertiniEmily GreggChris BartlettVij SenthilnathanMick ArberDeborah WatkinsSara GraziadioIoannis TomazosPublished in: Orphanet journal of rare diseases (2023)
These reviews highlight the limited HRQoL, utilities, costs and resource use data and the variability of instruments used in mitochondrial disease with associated seizures. However, the data available indicate that mitochondrial disease with associated seizures affects patients' and caregivers' HRQoL alike. No robust conclusion can be drawn on the impact of mitochondrial disease with associated seizures on hospital or ICU length of stay. Trial registration PROSPERO: CRD42022345005.
Keyphrases
- healthcare
- oxidative stress
- electronic health record
- big data
- clinical trial
- systematic review
- end stage renal disease
- randomized controlled trial
- chronic kidney disease
- intensive care unit
- ejection fraction
- emergency department
- study protocol
- palliative care
- risk factors
- data analysis
- acute respiratory distress syndrome
- health insurance
- extracorporeal membrane oxygenation
- acute care